Bottom line: The proposed cardiovascular benefits of fish oil supplements now seem uncertain. Some major studies are underway and may help clarify matters. In any case, your best bet is to get your omega-3s from two or three servings of fatty fish a week. The AHA continues to advise people with heart disease or high triglycerides to consider taking the supplements, after consulting their doctors. That’s still good advice if you don’t eat fish, especially since some of the other proposed benefits of omega-3s may still pan out. The supplements have few, if any, serious adverse effects—unless, that is, they lead you to think you can eat an unhealthy diet or can avoid taking the statins or other drugs you may need.